{"id":11116,"date":"2026-03-05T14:50:53","date_gmt":"2026-03-05T13:50:53","guid":{"rendered":"https:\/\/prenosznanja.si\/en\/?post_type=tehnologije&#038;p=11116"},"modified":"2026-04-03T15:13:05","modified_gmt":"2026-04-03T13:13:05","slug":"thermally-stable-insulin-with-preserved-biological-activity","status":"publish","type":"tehnologije","link":"https:\/\/prenosznanja.si\/en\/tehnologije\/thermally-stable-insulin-with-preserved-biological-activity\/","title":{"rendered":"Thermally Stable Insulin with Preserved Biological Activity"},"content":{"rendered":"\n<p><strong>Background<\/strong><\/p>\n\n\n\n<p>About 830 million people currently live with diabetes, projected to reach 1.3 billion by 2050. Insulin is essential but often inaccessible in low \u00a0and middle income regions due to strict cold chain requirements. Because current insulin must be stored at ~4\u202f\u00b0C, distribution is costly and prone to failures.<br>A heat stable, cold chain independent insulin would greatly expand access, reduce supply chain losses, and lower costs. The WHO has identified this need as urgent. Insulin\u2019s instability also reflects broader challenges in biologics, where many protein based therapeutics degrade easily. Incorporating non canonical building blocks offers a promising strategy to enhance protein stability across medicine and biotechnology.<\/p>\n\n\n\n<p><strong>Description of invention<\/strong><\/p>\n\n\n\n<p>Researchers introduced a novel non-canonical histidne analogue, having NH\u2011triazole building block, into specific positions of human insulin, enhancing intramolecular and intermolecular interactions that stabilize the molecule.<\/p>\n\n\n\n<p>Key Advantages<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Thermal stability up to 95\u202f\u00b0C<\/li>\n\n\n\n<li>Retains full biological activity after extreme heat exposure<\/li>\n\n\n\n<li>Increased resistance to enzymatic degradation<\/li>\n\n\n\n<li>Higher affinity for metal ions, enabling alternative stabilization and purification pathways<\/li>\n\n\n\n<li>Simplified production and distribution, potentially eliminating cold\u2011chain requirements<\/li>\n\n\n\n<li>This creates a high\u2011value, next\u2011generation insulin that could reshape the competitive landscape.<\/li>\n<\/ul>\n\n\n\n<p><strong>Main advantages<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Significant reduction in storage and transport costs<\/li>\n\n\n\n<li>Lower spoilage rates = improved margins<\/li>\n\n\n\n<li>Ability to penetrate untapped high\u2011population markets<\/li>\n\n\n\n<li>Competitive differentiation through superior formulation stability<\/li>\n\n\n\n<li>Potential for premium temperature\u2011stable insulin products<\/li>\n<\/ul>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The development of thermally stable, cold-chain-independent insulin represents an urgent solution that can significantly improve treatment accessibility while addressing broader stability challenges in biopharmaceuticals.<\/p>\n","protected":false},"author":4,"featured_media":11117,"menu_order":0,"template":"","tehnologije-kategorija-api":[579],"class_list":["post-11116","tehnologije","type-tehnologije","status-publish","has-post-thumbnail","hentry","tehnologije-kategorija-en-health"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - 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