{"id":11106,"date":"2026-03-03T17:36:34","date_gmt":"2026-03-03T16:36:34","guid":{"rendered":"https:\/\/prenosznanja.si\/en\/?post_type=tehnologije&#038;p=11106"},"modified":"2026-04-03T15:09:54","modified_gmt":"2026-04-03T13:09:54","slug":"novel-quinolin-2-yl-nitrones-useful-for-the-prevention-and-or-treatment-of-neurodegenerative-diseases","status":"publish","type":"tehnologije","link":"https:\/\/prenosznanja.si\/en\/tehnologije\/novel-quinolin-2-yl-nitrones-useful-for-the-prevention-and-or-treatment-of-neurodegenerative-diseases\/","title":{"rendered":"Novel quinolin-2-yl nitrones useful for the prevention and\/or treatment of neurodegenerative diseases"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>Background<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Alzheimer\u2019s disease is a neurodegenerative disease characterized by progressive deterioration of memory and learning ability due to a variety of pathological changes in the central nervous system. Parkinson\u2019s disease is a chronic neurodegenerative disease characterized by the progressive death of dopaminergic neurons. Due to the aging of the population, both diseases place an increasing burden on patients\u2019 families and healthcare systems. New therapeutic options are needed to mitigate the consequences of neurodegenerative diseases and improve the quality of life not only for patients but also for their families.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Description of invention<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The invention relates to quinolin-2-yl nitrones having formula\u00a0<strong>I<\/strong>, which can be used as drugs for the treatment of neurodegenerative diseases by inhibiting butyrylcholinesterase and monoamine oxidase B either alone or in combination with other beneficial activities, such as antioxidant properties and metal chelation. The present invention is being tested in animal models of neurodegenerative diseases, and our goal is to further develop it for human application.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Main advantages<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Drugs developed for the treatment of Alzheimer\u2019s and Parkinson\u2019s diseases usually have low activity and cause severe undesirable side effects. Our drug candidates act through different and innovative mechanisms of action that may provide better therapy and limit side effects.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Description<br \/>\nQuinolin-2-yl nitrones, targeting butyrylcholinesterase and monoamine oxidase B, offer a novel approach for treating Alzheimer&#8217;s and Parkinson&#8217;s diseases, with potential for better efficacy and fewer side effects compared to current therapies.<\/p>\n","protected":false},"author":4,"featured_media":0,"menu_order":0,"template":"","tehnologije-kategorija-api":[579],"class_list":["post-11106","tehnologije","type-tehnologije","status-publish","hentry","tehnologije-kategorija-en-health"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Novel quinolin-2-yl nitrones useful for the prevention and\/or treatment of neurodegenerative diseases | Knowledge Transfer 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