{"id":11103,"date":"2026-03-03T17:24:56","date_gmt":"2026-03-03T16:24:56","guid":{"rendered":"https:\/\/prenosznanja.si\/en\/?post_type=tehnologije&#038;p=11103"},"modified":"2026-04-03T15:07:16","modified_gmt":"2026-04-03T13:07:16","slug":"nn-dialkyl-4-2-ethylindan-2-yl-1h-imidazole-1-carboxamides-and-related-compounds-for-treatment-of-neurodegenerative-diseases","status":"publish","type":"tehnologije","link":"https:\/\/prenosznanja.si\/en\/tehnologije\/nn-dialkyl-4-2-ethylindan-2-yl-1h-imidazole-1-carboxamides-and-related-compounds-for-treatment-of-neurodegenerative-diseases\/","title":{"rendered":"N,N-dialkyl-4-(2-ethylindan-2-yl)-1H-imidazole-1-carboxamides and related compounds for treatment of neurodegenerative diseases"},"content":{"rendered":"\n<p><strong>Background<\/strong><\/p>\n\n\n\n<p>The most common type of dementia, Alzheimer\u2019s disease, is a neurodegenerative disease characterized by a progressive decline of memory and other cognitive functions due to a plethora of pathological changes in the central nervous system. By some estimates, over 50 million people are currently beset by Alzheimer\u2019s disease, with many more to follow due to the aging of the world\u2019s population. Therefore, new and efficient therapies are urgently needed to alleviate the disease\u2019s toll on the patients, their loved ones, and healthcare systems.<\/p>\n\n\n\n<p><strong>Description of invention<\/strong><\/p>\n\n\n\n<p>The invention relates to imidazole-1-carboxamides that have a dual mode of action \u2013 i.e., act as \u03b1<sub>2<\/sub>\u00a0adrenoreceptor antagonists and cholinesterase inhibitors, as disease-modifying treatment for Alzheimer\u2019s disease and other neurodegenerative diseases. The present invention is currently being tested in animal models of neurodegenerative diseases, and our goal is to further develop it for human application.<\/p>\n\n\n\n<p><strong>Main advantages<\/strong><\/p>\n\n\n\n<p>The compounds presented act as pleiotropic prodrugs, which undergo metabolic activation with butyrylcholinesterase (pseudo-irreversibly inactivating the enzyme in the process, thus achieving the first therapeutic effect) to liberate the adrenergic antagonist atipamezole. The latter binds to \u03b1<sub>2A<\/sub>&nbsp;adrenoreceptors in the brain, blocking their activation by amyloid \u03b2 oligomers, and so prevents&nbsp;<em>tau<\/em>&nbsp;hyperphosphorylation further down the signalling cascade (second therapeutic effect).<\/p>\n\n\n\n<p>Thus, our drug candidates act through different and innovative mechanisms that are expected to have a disease-modifying effect in addition to the transient improvement of the patients\u2019 cognitive status.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>This invention presents imidazole-1-carboxamides as dual-action compounds for Alzheimer\u2019s and other neurodegenerative diseases. They act as \u03b12 adrenoreceptor antagonists and cholinesterase inhibitors to both modify disease progression and improve cognitive function, with effects currently being tested in animal models.<\/p>\n","protected":false},"author":4,"featured_media":0,"menu_order":0,"template":"","tehnologije-kategorija-api":[579],"class_list":["post-11103","tehnologije","type-tehnologije","status-publish","hentry","tehnologije-kategorija-en-health"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>N,N-dialkyl-4-(2-ethylindan-2-yl)-1H-imidazole-1-carboxamides and related compounds for treatment of neurodegenerative diseases - Knowledge Transfer Slovenia | Slovenian Science in One Place<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/prenosznanja.si\/en\/tehnologije\/nn-dialkyl-4-2-ethylindan-2-yl-1h-imidazole-1-carboxamides-and-related-compounds-for-treatment-of-neurodegenerative-diseases\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"N,N-dialkyl-4-(2-ethylindan-2-yl)-1H-imidazole-1-carboxamides and related compounds for treatment of neurodegenerative diseases - Knowledge Transfer Slovenia | Slovenian Science in One Place\" \/>\n<meta property=\"og:description\" content=\"This invention presents imidazole-1-carboxamides as dual-action compounds for Alzheimer\u2019s and other neurodegenerative diseases. They act as \u03b12 adrenoreceptor antagonists and cholinesterase inhibitors to both modify disease progression and improve cognitive function, with effects currently being tested in animal models.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/prenosznanja.si\/en\/tehnologije\/nn-dialkyl-4-2-ethylindan-2-yl-1h-imidazole-1-carboxamides-and-related-compounds-for-treatment-of-neurodegenerative-diseases\/\" \/>\n<meta property=\"og:site_name\" content=\"Knowledge Transfer Slovenia | Slovenian Science in One Place\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-03T13:07:16+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/prenosznanja.si\\\/en\\\/tehnologije\\\/nn-dialkyl-4-2-ethylindan-2-yl-1h-imidazole-1-carboxamides-and-related-compounds-for-treatment-of-neurodegenerative-diseases\\\/\",\"url\":\"https:\\\/\\\/prenosznanja.si\\\/en\\\/tehnologije\\\/nn-dialkyl-4-2-ethylindan-2-yl-1h-imidazole-1-carboxamides-and-related-compounds-for-treatment-of-neurodegenerative-diseases\\\/\",\"name\":\"N,N-dialkyl-4-(2-ethylindan-2-yl)-1H-imidazole-1-carboxamides and related compounds for treatment of neurodegenerative diseases - Knowledge Transfer Slovenia | Slovenian Science in One Place\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/prenosznanja.si\\\/en\\\/#website\"},\"datePublished\":\"2026-03-03T16:24:56+00:00\",\"dateModified\":\"2026-04-03T13:07:16+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/prenosznanja.si\\\/en\\\/tehnologije\\\/nn-dialkyl-4-2-ethylindan-2-yl-1h-imidazole-1-carboxamides-and-related-compounds-for-treatment-of-neurodegenerative-diseases\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/prenosznanja.si\\\/en\\\/tehnologije\\\/nn-dialkyl-4-2-ethylindan-2-yl-1h-imidazole-1-carboxamides-and-related-compounds-for-treatment-of-neurodegenerative-diseases\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/prenosznanja.si\\\/en\\\/tehnologije\\\/nn-dialkyl-4-2-ethylindan-2-yl-1h-imidazole-1-carboxamides-and-related-compounds-for-treatment-of-neurodegenerative-diseases\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/prenosznanja.si\\\/en\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Inovacije\",\"item\":\"https:\\\/\\\/prenosznanja.si\\\/en\\\/tehnologije\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"N,N-dialkyl-4-(2-ethylindan-2-yl)-1H-imidazole-1-carboxamides and related compounds for treatment of neurodegenerative diseases\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/prenosznanja.si\\\/en\\\/#website\",\"url\":\"https:\\\/\\\/prenosznanja.si\\\/en\\\/\",\"name\":\"Knowledge Transfer Slovenia | Slovenian Science in One Place\",\"description\":\"Slovenian Science in One Place.\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/prenosznanja.si\\\/en\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"N,N-dialkyl-4-(2-ethylindan-2-yl)-1H-imidazole-1-carboxamides and related compounds for treatment of neurodegenerative diseases - Knowledge Transfer Slovenia | Slovenian Science in One Place","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/prenosznanja.si\/en\/tehnologije\/nn-dialkyl-4-2-ethylindan-2-yl-1h-imidazole-1-carboxamides-and-related-compounds-for-treatment-of-neurodegenerative-diseases\/","og_locale":"en_US","og_type":"article","og_title":"N,N-dialkyl-4-(2-ethylindan-2-yl)-1H-imidazole-1-carboxamides and related compounds for treatment of neurodegenerative diseases - Knowledge Transfer Slovenia | Slovenian Science in One Place","og_description":"This invention presents imidazole-1-carboxamides as dual-action compounds for Alzheimer\u2019s and other neurodegenerative diseases. They act as \u03b12 adrenoreceptor antagonists and cholinesterase inhibitors to both modify disease progression and improve cognitive function, with effects currently being tested in animal models.","og_url":"https:\/\/prenosznanja.si\/en\/tehnologije\/nn-dialkyl-4-2-ethylindan-2-yl-1h-imidazole-1-carboxamides-and-related-compounds-for-treatment-of-neurodegenerative-diseases\/","og_site_name":"Knowledge Transfer Slovenia | Slovenian Science in One Place","article_modified_time":"2026-04-03T13:07:16+00:00","twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/prenosznanja.si\/en\/tehnologije\/nn-dialkyl-4-2-ethylindan-2-yl-1h-imidazole-1-carboxamides-and-related-compounds-for-treatment-of-neurodegenerative-diseases\/","url":"https:\/\/prenosznanja.si\/en\/tehnologije\/nn-dialkyl-4-2-ethylindan-2-yl-1h-imidazole-1-carboxamides-and-related-compounds-for-treatment-of-neurodegenerative-diseases\/","name":"N,N-dialkyl-4-(2-ethylindan-2-yl)-1H-imidazole-1-carboxamides and related compounds for treatment of neurodegenerative diseases - Knowledge Transfer Slovenia | Slovenian Science in One Place","isPartOf":{"@id":"https:\/\/prenosznanja.si\/en\/#website"},"datePublished":"2026-03-03T16:24:56+00:00","dateModified":"2026-04-03T13:07:16+00:00","breadcrumb":{"@id":"https:\/\/prenosznanja.si\/en\/tehnologije\/nn-dialkyl-4-2-ethylindan-2-yl-1h-imidazole-1-carboxamides-and-related-compounds-for-treatment-of-neurodegenerative-diseases\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/prenosznanja.si\/en\/tehnologije\/nn-dialkyl-4-2-ethylindan-2-yl-1h-imidazole-1-carboxamides-and-related-compounds-for-treatment-of-neurodegenerative-diseases\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/prenosznanja.si\/en\/tehnologije\/nn-dialkyl-4-2-ethylindan-2-yl-1h-imidazole-1-carboxamides-and-related-compounds-for-treatment-of-neurodegenerative-diseases\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/prenosznanja.si\/en\/"},{"@type":"ListItem","position":2,"name":"Inovacije","item":"https:\/\/prenosznanja.si\/en\/tehnologije\/"},{"@type":"ListItem","position":3,"name":"N,N-dialkyl-4-(2-ethylindan-2-yl)-1H-imidazole-1-carboxamides and related compounds for treatment of neurodegenerative diseases"}]},{"@type":"WebSite","@id":"https:\/\/prenosznanja.si\/en\/#website","url":"https:\/\/prenosznanja.si\/en\/","name":"Knowledge Transfer Slovenia | Slovenian Science in One Place","description":"Slovenian Science in One Place.","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/prenosznanja.si\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"}]}},"featured_img":false,"coauthors":[],"author_meta":{"author_link":"https:\/\/prenosznanja.si\/en\/author\/petravanic\/","display_name":"petravanic"},"relative_dates":{"created":"Posted 2 months ago","modified":"Updated 2 weeks ago"},"absolute_dates":{"created":"Posted on 03.03.2026","modified":"Updated on 03.04.2026"},"absolute_dates_time":{"created":"Posted on 03.03.2026 5:24 pm","modified":"Updated on 03.04.2026 3:07 pm"},"featured_img_caption":"","tax_additional":{"tehnologije-kategorija-en":{"linked":["<a href=\"https:\/\/prenosznanja.si\/en\/tehnologije-kategorija-en\/health\/\" class=\"advgb-post-tax-term\">Health<\/a>"],"unlinked":["<span class=\"advgb-post-tax-term\">Health<\/span>"],"slug":"tehnologije-kategorija-en","name":"Fields Innovation &amp; Spinout"}},"series_order":"","_links":{"self":[{"href":"https:\/\/prenosznanja.si\/en\/wp-json\/wp\/v2\/tehnologije\/11103","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/prenosznanja.si\/en\/wp-json\/wp\/v2\/tehnologije"}],"about":[{"href":"https:\/\/prenosznanja.si\/en\/wp-json\/wp\/v2\/types\/tehnologije"}],"wp:attachment":[{"href":"https:\/\/prenosznanja.si\/en\/wp-json\/wp\/v2\/media?parent=11103"}],"wp:term":[{"taxonomy":"tehnologije-kategorija-en","embeddable":true,"href":"https:\/\/prenosznanja.si\/en\/wp-json\/wp\/v2\/tehnologije-kategorija-api?post=11103"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}