Disruption of bacterial biofilms by magnetic nanochains

Background

Antimicrobial resistance is a critical global public health threat and tough scientific
and developmental challenge. Antibiotic-resistant infections cause millions of deaths
worldwide. As bacteria develop resistance to antibiotics, the burden on global health
intensifies, leading to untreatable infections, prolonged illnesses, and a looming crisis
where routine medical procedures and surgeries become perilously risky. Biofilms
significantly contribute to the failure of antibiotic therapies, making it imperative to
target and eradicate biofilms to combat antibiotic resistance effectively.

Description of invention

This invention encompasses a method for biofilm eradication using propelling highly
magneto-responsive anisotropic iron oxide nanochains as nanomixers, activated by a
classical low frequency magnetic stirrer applying low intensity rotating magnetic
fields. The method enables localized disintegration of the biofilm, enhances
penetration, and thus improves the efficacy of antibiotic agents. Nanochains
effectively disrupt the biofilm and sensitize bacteria to antibiotics.

Main advantages

• Biofilm disruption
• Sensitization of bacteria to existing antibiotics
• Biocompatible and non-toxic / safe to mammalian cells